Endocannabinoids, Phytocannabinoids & MS
All of us have something known as an endocannabinoid system (ECS) consisting of receptors, neurotransmitters known as endocannabinoids, and enzymes that break these down once they served their purpose (read more about it here ).
However, endocannabinoids are a special type of neurotransmitter that are able to not only affect “receiver” neurons, but also “sender” neurons. When a postsynaptic neuron gets triggered, endocannabinoid production is activated, from where they travel “backwards” up the axon towards the presynaptic neuron, functioning like a dimmer-switch that suppresses neurotransmitter release and neural activity. Essentially, this means that the way in which neural impulses are sent, neurotransmitters are released, and how these are processed by the CNS is primarily mediated by the ECS.